The Unknown Health Problems Purebred Cats Are Most Likely To Face

Nov 30, 2025byMichael Tremblay

Purebred cats often capture hearts with their striking looks and distinctive personalities, but those same traits sometimes come with hidden health challenges.

Selective breeding can concentrate genes that make certain breeds more prone to specific issues, from heart conditions in Maine Coons to breathing difficulties in Persians.

While many purebreds live long, happy lives with proper care, understanding their potential vulnerabilities helps owners spot early warning signs and make informed choices.

All information is provided for general interest only. Consult a qualified veterinarian for any health-related concerns. Photos are for illustrative purposes only.

Polycystic Kidney Disease In Persian Cats

Polycystic Kidney Disease In Persian Cats
Image Credit: © Xue Guangjian / Pexels

Persian cats carry a genetic mutation that causes fluid-filled cysts to develop in their kidneys over time.

This condition often goes unnoticed until the kidneys have already suffered significant damage, usually when the cat reaches middle age.

Symptoms include increased thirst, frequent urination, and weight loss.

Regular veterinary checkups with blood tests can help detect kidney problems before they become severe.

Breeders now use genetic testing to identify carriers, so asking about PKD screening when choosing a kitten could save heartache later.

Early detection allows for dietary changes and medications that may slow progression.

Hypertrophic Cardiomyopathy In Maine Coons

Hypertrophic Cardiomyopathy In Maine Coons
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Maine Coons are prone to developing thickened heart muscle walls, which makes it harder for their hearts to pump blood effectively.

Many cats show no symptoms until the disease has progressed considerably, making this a particularly sneaky condition.

Some warning signs include rapid breathing, lethargy, and decreased appetite.

Unfortunately, sudden collapse or paralysis of the hind legs can be the first noticeable symptom in severe cases.

Annual heart screenings with ultrasound can catch this problem early.

Medications exist that may help manage symptoms and improve quality of life, though there’s currently no cure for this inherited condition.

Progressive Retinal Atrophy In Abyssinians

Progressive Retinal Atrophy In Abyssinians
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Abyssinians can inherit a gene that causes their retinas to deteriorate gradually, eventually leading to complete blindness.

Cats typically start showing signs between ages three and five, beginning with difficulty seeing in dim light.

Owners might notice their cat bumping into furniture at night or becoming hesitant in darkened rooms.

As the condition worsens, daytime vision also declines.

While there’s no treatment to stop or reverse this disease, cats adapt remarkably well to vision loss when it happens gradually.

Keeping furniture in the same places and using scent markers helps blind cats navigate confidently around their homes.

Patellar Luxation In Devon Rex Cats

Patellar Luxation In Devon Rex Cats
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The kneecap in Devon Rex cats sometimes slips out of its proper position, causing pain and an abnormal gait.

This happens because the groove where the kneecap sits is too shallow, allowing it to move sideways when the cat walks or runs.

You might see your cat suddenly holding up one back leg while walking, then using it normally again moments later.

In severe cases, surgery may be necessary to deepen the groove and keep the kneecap stable.

Maintaining a healthy weight reduces stress on the joints.

Supplements containing glucosamine might help support joint health, though you should consult your veterinarian before starting any supplements.

Amyloidosis In Siamese Breeds

Amyloidosis In Siamese Breeds
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Siamese cats and related breeds face a higher risk of abnormal protein deposits building up in their organs, particularly the liver and kidneys.

These deposits interfere with normal organ function and can lead to organ failure if left unchecked.

Early symptoms are vague and easy to miss, including reduced appetite and occasional vomiting.

As the disease progresses, jaundice may develop, turning the gums and whites of the eyes yellowish.

Blood tests and biopsies help confirm diagnosis.

Treatment focuses on managing symptoms and supporting organ function, though the prognosis depends heavily on how much damage has occurred before detection and which organs are affected.

Respiratory Issues In Flat-Faced Breeds

Respiratory Issues In Flat-Faced Breeds
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Breeds like Persians, Himalayans, and Exotic Shorthairs have been bred to have extremely flat faces, which unfortunately comes with serious breathing difficulties.

Their compressed nasal passages, elongated soft palates, and narrowed windpipes make every breath a struggle.

You’ll often hear these cats snoring, wheezing, or breathing noisily even during normal activities.

They overheat easily because they can’t cool themselves efficiently through panting.

Avoid strenuous exercise and keep them in air-conditioned spaces during hot weather.

Surgical procedures can widen airways in severe cases, significantly improving quality of life for cats who struggle to breathe comfortably.

Spinal Muscular Atrophy in Maine Coons

Spinal Muscular Atrophy in Maine Coons
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Some Maine Coon kittens inherit a mutation that causes motor neurons in their spinal cord to die off, leading to progressive muscle weakness.

Symptoms typically appear when kittens are just a few months old, starting with a wobbly gait and difficulty jumping.

Affected kittens have normal intelligence and sensation but struggle with muscle control.

Their back legs and trunk muscles weaken over time, though the condition usually stabilizes rather than continuing to worsen throughout life.

There’s no cure, but affected cats can live happy lives with accommodations like ramps, padded surfaces, and assistance with grooming.

Genetic testing before breeding helps eliminate this gene from breeding lines.

Gingivostomatitis in Purebred Populations

Gingivostomatitis in Purebred Populations
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Certain purebred lines show increased susceptibility to severe, chronic mouth inflammation that causes extreme pain when eating.

The exact cause remains unclear, but it likely involves an overactive immune response to bacteria normally present in the mouth.

Affected cats drool excessively, drop food while eating, and may stop grooming themselves.

Their gums become bright red and inflamed, sometimes developing ulcers.

Treatment often requires extracting most or all teeth, which sounds drastic but usually provides dramatic relief.

Cats manage surprisingly well without teeth since they don’t chew their food much anyway.

Anti-inflammatory medications and immune suppressants may help in less severe cases.

Michael Tremblay
byMichael Tremblay

A nature enthusiast from Montreal with a background in wildlife photography. Michael writes about wildlife, conservation efforts, and the beauty of animals in their natural habitats.